Perioperative medicine & outcomes
Early mortality in patients with acute promyelocytic leukemia: a systematic review and meta-analysis
Authors' conclusion
There is an encouraging decrease over time of early mortality in patients with APL. Early mortality is lower in interventional studies.
Study context
- Population
- Patients with newly diagnosed acute promyelocytic leukemia (APL)
- Participants
- 54,923 patients · 140 studies
- Comparison
- Interventional vs observational studies
- Outcome
- Early mortality (death within 30 days following diagnosis)
- Follow-up
- 30 days
Methodological detailsrandom effects model, meta-regression
- Random effects model
- Meta-regression
Pooled result
As reported in the abstract
Early mortality
Meta-analytical early mortality rate across 122 studies
12%
Further pooled results
Early mortality by study type (subgroup)
Causes of early mortality
- Hemorrhage (main cause)
- 57%
- Sepsis
- 18%
- Differentiation syndrome (DS)
- 12%
- Thrombotic events
- 2%
Factors associated with early mortality (meta-regression)
- Early mortality influenced by age, white blood cell count at diagnosis, time, study type and country income classification
Original publication
Early mortality in patients with acute promyelocytic leukemia: a systematic review and meta-analysis. Crit Care. Published 14 November 2025. doi:10.
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