Perioperative medicine & outcomes
Respiratory Exchange Ratio guided management in high-risk noncardiac surgery: The OPHIQUE multicentre randomised controlled trial
Primary resultResult — go to the resultRelative risk 0.93 95% CI 0.75–1.17Authors' conclusion
In high-risk surgery, a goal-directed therapy algorithm integrating the measurement of the respiratory-exchange ratio did not reduce a composite outcome of major postoperative complications or death within seven days after surgery compared to routine care.
Study context
- Population
- Patients at high risk of postoperative complications undergoing high-risk noncardiac surgery lasting 2 h or longer under GAenrolled
- Participants
- 350 patients
- Comparison
- Interventional vs Control
- Primary endpoint
- Composite of:
- Major complications
- Death
- Follow-up
- Within seven days of surgery
Methodological detailsmulticentre, Four university medical centres and one non-university hospital, December 26, 2018, to September 9, 2021
- Multicentre
- Four university medical centres and one non-university hospital, December 26, 2018, to September 9, 2021
Primary result
As reported in the abstract
Relative risk
0.93
95% CI 0.75–1.17
P = 0.55
Events by treatment group
Interventional vs Control
RR 0.93 (95% CI 0.75–1.17); P = 0.55
Secondary outcomes
Hospital LOS, 30-day mortality, total intraoperative fluid volume
- No clinically relevant differences between the two groups
Original publication
Respiratory Exchange Ratio guided management in high-risk noncardiac surgery: The OPHIQUE multicentre randomised controlled trial. Anaesth Crit Care Pain Med. Published 21 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →