ICU sedation, delirium & recovery
Early sedation using ciprofol for intensive care unit patients requiring mechanical ventilation: a pooled post-hoc analysis of data from phase 2 and phase 3 trials
Authors' conclusion
ICU patients undergoing mechanical ventilation and sedated with ciprofol had significantly lower rate of hypotension during the early phase of achieving light sedation during a 6-24 h period, leading to a more favorable short-term prognosis (within 24 h).
Study context
- Population
- Intensive care unit (ICU) patients requiring mechanical ventilation and expected to require sedation for 6–24 h, target light sedation (RASS −2 to +1)
- Participants
- 174 patients
- Comparison
- Ciprofol vs Propofol
- Ciprofoln = 116
- Propofoln = 58reference
- Primary endpoint
- Hypotension-free rate in patients who achieved the target sedation goal after 30-min administration
Methodological details2:1 randomisation
- 2:1 randomisation
Primary result
As reported in the abstract
Hypotension-free rate among patients reaching target sedation after 30 min
P = 0.018
Further findings
Hypotension-free rate in subgroups (males; age < 65 years)
- Higher hypotension-free rate with ciprofol especially in males and patients aged < 65 years
Independent predictors of hypotension-free rate (multivariable analysis)
- Ciprofol treatment, younger age and lower baseline BMI were independent favorable predictors
Short-term prognosis of hypotension-free vs other patients reaching target sedation after 30 min
- Hypotension-free patients had fewer drug-related treatment-emergent adverse events, shorter time to extubation and fewer dose adjustments (all P < 0.05)
Original publication
Early sedation using ciprofol for intensive care unit patients requiring mechanical ventilation: a pooled post-hoc analysis of data from phase 2 and phase 3 trials. Ann Intensive Care. Published 26 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →