Pediatric anesthesia & critical care
Early T-Lymphocyte Depletion Predicts Mortality in Critically Ill Children With Severe Infections: An Exploratory Analysis of Cytokine Pathways
Main finding · 90-day mortalityResult — go to the resultHazard ratio 2.62 95% CI 1.12–6.14Authors' conclusion
Early T cell depletion independently predicts mortality in critically ill children with severe infections.
Study context
- Population
- Children 28 days to 18 years admitted to a 55-bed PICU with infections, excluding preexisting conditions affecting T cell counts
- Participants
- 252 children
- Exposure
- Lower vs higher CD3+ T cell count
- Outcome
- 90-day mortality
- Follow-up
- 90 days
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
2.62
95% CI 1.12–6.14
Lower T cell vs Higher T cell
HR 2.62 (95% CI 1.12–6.14)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Mortality (Kaplan-Meier)Significantly higher mortality in lower T cell group | P = 0.011 |
30-, 60- and 90-day mortality
- Markedly increased mortality in the lower T cell group
- P < 0.05
Mediation by PDGF-AA
- Proportion of total pathway mediated by PDGF-AA
- 71.19%
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Early T-Lymphocyte Depletion Predicts Mortality in Critically Ill Children With Severe Infections: An Exploratory Analysis of Cytokine Pathways. Crit Care Med. Published 22 January 2026. doi:10.
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