Echocardiographic profiles and hemodynamic response after vasopressin initiation in septic shock: A cross-sectional study
Authors' conclusion
Pre-drug echocardiographic profiles differed in hemodynamic responders after vasopressin initiation versus non-responders.
Study context
- Population
- Adults with septic shock receiving catecholamines and vasopressin, with an echocardiogram after shock onset but before vasopressin initiation
- Participants
- 129 adults
- Exposure
- Hemodynamic responders vs non-responders after vasopressin initiation
- Respondersn = 72
- Outcome
- Echocardiographic parameters (LV ejection fraction (LVEF); Left ventricular (LV) systolic dysfunction = LVEF <45%) by hemodynamic response
Methodological detailsretrospective, single-centre
- Retrospective
- Single-centre
Main finding
As reported in the abstract
LVEF
P = 0.02
Observational data: associations, not effects.
Further findings
| Outcome | Absolute difference (95% CI) | |
|---|---|---|
| LV systolic dysfunctionLess frequent in responders | −16% (−30%,−2%) | |
| −40−20020Difference (linear scale) |
| Outcome | Estimate | |
|---|---|---|
| Hemodynamic response per 10% higher LVEF | OR 1.32 (95% CI 1.04–1.68) | |
| Mortality, LV systolic dysfunction vs none · t = 0HR(t) = e[0.81-0.1*t] | HR 2.24 (95% CI 1.08–4.64) | |
| 0.20.5125Ratio (log scale) |
Original publication
Echocardiographic profiles and hemodynamic response after vasopressin initiation in septic shock: A cross-sectional study. J Crit Care. Published 6 April 2023. doi:10.
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