An educational intervention to reduce the incidence of postoperative residual curarisation: a cluster randomised crossover trial in patients undergoing general anaesthesia
Authors' conclusion
An educational intervention on perioperative neuromuscular block management did not reduce the incidence of postoperative residual curarisation nor increase reversal, despite increased quantitative neuromuscular monitoring.
Study context
- Population
- Patients undergoing GA in 34 Spanish centres
- Participants
- 2,314 patients · 34 Spanish centres
- Comparison
- Educational intervention vs No intervention
- Primary endpoint
- Postoperative residual curarisation in the PACU
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Postoperative residual curarisation
Educational intervention vs No interventionOdds ratio (95% CI)P value
First time-period interaction
0.90(0.51–1.58)
P = 0.717Second time-period interaction
1.30(0.73–2.30)
P = 0.371Secondary outcomes
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Quantitative neuromuscular monitor usage | 2.04 (1.31–3.19) | P = 0.002 | |
| Use of reversal agentsUnchanged | 0.79 (0.50–1.26) | P = 0.322 | |
| PPCs during hospital stay | 0.19 (0.10–0.35) | P < 0.001 | |
| 0.10.31310Odds ratio (log scale) |
Original publication
An educational intervention to reduce the incidence of postoperative residual curarisation: a cluster randomised crossover trial in patients undergoing general anaesthesia. Br J Anaesth. Published 20 April 2023. doi:10.
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