Cardiac arrest & resuscitation
Early electroencephalogram (EEG) based predictions of good outcome after cardiac arrest improve with sevoflurane sedation, as compared with propofol
Authors' conclusion
In this non-randomised two-centre cohort study, sevoflurane sedation was associated with less frequent discontinuous EEG 12 h after cardiac arrest, enabling earlier and reliable prediction of good outcome. Prediction of poor outcome was reliable with both sevoflurane and propofol. However, potential bias due to differences in temperature management cannot be excluded.
Study context
- Population
- Comatose adults (≥18) admitted to the ICU after resuscitation from cardiac arrest, two Dutch teaching hospitals
- Participants
- 412 adults
- Exposure
- Sevoflurane vs propofol sedation for early EEG prognostication
- Sevofluranen = 51
- Propofoln = 361reference
- Outcome
- Prognostic value of early EEG for good (CPC 1–2) vs poor (CPC 3–5) outcome at 6 months
- Follow-up
- EEG at 12 and 24 h after cardiac arrest
Methodological detailstwo-centre, non-randomised
- Two-centre
- Non-randomised
Main finding
As reported in the abstract
Prediction of good outcome by EEG · 12 h after cardiac arrest
| Group | Sensitivity | Specificity |
|---|---|---|
| Sevoflurane | 0.89 (95% CI 0.62-1.00) | 0.71 (95% CI 0.44-0.91) |
| Propofol | 0.42 (95% CI 0.34-0.50) | 0.88 (95% CI 0.81-0.92) |
Sensitivity
Sevoflurane0.89 (95% CI 0.62-1.00)
Propofol0.42 (95% CI 0.34-0.50)
Specificity
Sevoflurane0.71 (95% CI 0.44-0.91)
Propofol0.88 (95% CI 0.81-0.92)
Observational data: associations, not effects.
Further findings
Prediction of good outcome by EEG at 24 h · 24 h after cardiac arrest
- No significant differences in sensitivity and specificity between sevoflurane and propofol
Prediction of poor outcome by EEG · 12 and 24 h after cardiac arrest
- No significant differences in sensitivity and specificity between sevoflurane and propofol
Original publication
EEG based predictions of good outcome after cardiac arrest improve with sevoflurane sedation, as compared with propofol. Resuscitation. Published 15 October 2025. doi:10.
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