Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands
Primary result · EQ-5D-5L health utility score during 180 daysResult — go to the resultMean difference −0.05 95% CI −0.10 to −0.01Authors' conclusion
High enteral protein provision compared with standard enteral protein provision resulted in worse health-related quality of life in critically ill patients and did not improve functional outcomes during 180 days after ICU admission.
Study context
- Population
- Critically ill adults on invasive mechanical ventilation started within 24 h of intensive care unit (ICU) admission, expected ventilation ≥3 days; five Dutch and five Belgian hospitalsrandomly assigned
- Participants
- 935 adults
- Comparison
- High vs standard enteral protein provision
- Standard proteinn = 465reference
- High proteinn = 470
- Primary endpoint
- EQ-5D-5L health utility score, adjusted for baseline score
- Follow-up
- 30, 90 and 180 days after randomisation
Methodological detailsinvestigator-initiated, double-blinded, multicentre, parallel-group
- Investigator-initiated
- Double-blinded
- Multicentre
- Parallel-group
Primary result
EQ-5D-5L health utility score during 180 days · 30, 90 and 180 days
Mean difference
−0.05
95% CI −0.10 to −0.01
P = 0.031
High protein vs Standard protein
mean difference −0.05 (95% CI −0.10 to −0.01); P = 0.031
As reported in the abstract
Further findings
Probability
| Outcome | Standard protein | High protein | HR (95% CI) | P value | |
|---|---|---|---|---|---|
| Mortality during entire follow-up | 0.38 (SE 0.02) | 0.42 (SE 0.02) | 1.14 (0.92–1.40) | P = 0.22 | |
| 0.512Hazard ratio (log scale) |
Safety
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Symptoms of gastrointestinal intoleranceHigher incidence in high protein | 1.76 (1.06–2.92) | P = 0.030 | |
| 0.20.5125Odds ratio (log scale) |
Other adverse events
- Incidence did not differ between groups
Original publication
Effect of high versus standard protein provision on functional recovery in people with critical illness (PRECISe): an investigator-initiated, double-blinded, multicentre, parallel-group, randomised controlled trial in Belgium and the Netherlands. Lancet. Published 17 August 2024. doi:10.
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