Pediatric anesthesia & critical care
The effect of intranasal dexmedetomidine administration on emergence agitation or delirium in pediatric patients after general anesthesia: A meta‐analysis of randomized controlled trials
Pooled resultResult — go to the resultOdds ratio 0.25 95% CI 0.18–0.34Authors' conclusion
Intranasal dexmedetomidine reduced the incidence of emergence agitation or emergence delirium in pediatric patients after general anesthesia.
Study context
- Population
- Pediatric patients after GA
- Participants
- 2,103 patients · 20 RCTs
- Comparison
- Intranasal dexmedetomidine vs control
- Outcome
- Proportion of patients with emergence agitation or emergence delirium after surgery
Methodological detailsrandom-effects model
- Random-effects model
Pooled result
As reported in the abstract
Odds ratio
0.25
95% CI 0.18–0.34
P = 0.0000
By group
Dexmedetomidine vs Control
OR 0.25 (95% CI 0.18–0.34); P = 0.0000
Further pooled results
| Outcome | MD (95% CI) | P value | |
|---|---|---|---|
| Emergence timeI2 = 98.40% | 2.42 (0.37–4.46) | P = 0.021 | |
| −20246Difference (linear scale) |
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Postoperative nausea and/or vomitingI2 = 0.00% | 0.39 (0.24–0.64) | P = 0.0002 | |
| 0.20.5125Odds ratio (log scale) |
Original publication
The effect of intranasal dexmedetomidine administration on emergence agitation or delirium in pediatric patients after general anesthesia: A meta‐analysis of randomized controlled trials. Paediatr Anaesth. Published 1 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →