The Effect of Intrathecal Morphine on Postoperative Opioid Consumption in Patients Undergoing Abdominal Surgery for Gynecologic Malignancy: A Randomized Sham-Controlled Trial
Authors' conclusion
ITM is a safe and effective analgesic method after curative intent laparotomy for gynecologic malignancy.
Study context
- Population
- Adults undergoing open gynecologic oncology surgery (midline laparotomy for gynecologic malignancy)
- Participants
- 68 adults
- Comparison
- Intrathecal morphine 200 μg vs sham procedure
- Primary endpoint
- Cumulative intravenous (IV) opioid consumption
- Follow-up
- 24 hours after surgery
Methodological detailssham-controlled
- Sham-controlled
Primary result
As reported in the abstract
Median difference
13
95% CI 7.2–20.7
P < 0.001
By group
ITM vs Sham
median difference 13 (95% CI 7.2–20.7); P < 0.001
Further findings
Patient satisfaction with pain control · 24 and 48 hours
- Significantly higher in intrathecal morphine (ITM) vs Sham at 24 h
- P < 0.001
- Significantly higher in ITM vs Sham at 48 h
- P = 0.005
Postoperative recovery variables
- No significant differences between groups
Safety
Complications requiring treatment
- No significant difference in frequency between groups
Original publication
The Effect of Intrathecal Morphine on Postoperative Opioid Consumption in Patients Undergoing Abdominal Surgery for Gynecologic Malignancy: A Randomized Sham-Controlled Trial. Anesth Analg. Published 20 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →