Respiratory failure & ventilation
Effect of a pre-emptive 2-hour session of high-flow nasal oxygen on postoperative oxygenation after major gynaecologic surgery: a randomised clinical trial
Primary resultResult — go to the resultMean difference 8.7 kPa 95% CI 3.4–13.9Authors' conclusion
In patients who underwent major gynaecological surgery, a pre-emptive 2-h session of HFNO after extubation improved postoperative oxygen exchange and reduced atelectasis compared with a conventional oxygen treatment strategy.
Study context
- Population
- Adult women after major gynaecological surgery in the Trendelenburg position
- Participants
- 83 women
- Comparison
- High-flow nasal oxygen (HFNO) vs Conventional treatment
- HFNOn = 42
- Conventional treatmentn = 41reference
- Primary endpoint
- PaO2/FiO2 ratio
- Follow-up
- After 2 h of treatment
Methodological detailssingle-centre, open-label
- Single-centre
- Open-label
Primary result
As reported in the abstract
Mean difference
8.7 kPa
95% CI 3.4–13.9
P = 0.003
By group
HFNO vs Conventional treatment
mean difference 8.7 kPa (95% CI 3.4–13.9); P = 0.003
Secondary outcomes
Impaired gas exchange (PaO2/FiO2 ≤40 kPa) · after 2 h of treatment
P < 0.001
| Outcome | HFNO | Conventional treatment | P value |
|---|---|---|---|
| Lung ultrasound scoreLower in HFNO | 9 (range as printed 6–10) | 12 (range as printed 10–14) | P < 0.001 |
| Lung ultrasound score, dorsal areas | 7 (range as printed 6–8) | 10 (range as printed 9–10) | P < 0.001 |
Diaphragm thickening fraction, dyspnoea, ventilatory frequency, PaCO2, PPCs at 30 days
- Not different between groups
Original publication
Effect of a pre-emptive 2-hour session of high-flow nasal oxygen on postoperative oxygenation after major gynaecologic surgery: a randomised clinical trial. Br J Anaesth. Published 4 August 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →