Effect of an opioid-free anesthetic on postoperative opioid consumption after laparoscopic bariatric surgery: a prospective, single-blinded, randomized controlled trial
Authors' conclusion
This study demonstrates that an OFA protocol using dexmedetomidine, ketamine, and lidocaine for laparoscopic or robotic bariatric surgery was not associated with a reduction in 24-hour postoperative opioid consumption when compared with an opioid-inclusive technique using fentanyl.
Study context
- Population
- Patients undergoing laparoscopic or robotic bariatric surgerycompleted per protocol
- Participants
- 181 patients
- Comparison
- Opioid-free anesthesia vs standard opioid-inclusive anesthesia
- Opioid-free anesthesia (OFA)n = 95
- Controln = 86reference
- Primary endpoint
- Opioid consumption in oral morphine equivalents (OMEs)
- Follow-up
- First 24 hours postoperatively
Methodological detailsprospective, single-blinded
- Prospective
- Single-blinded
Primary result
As reported in the abstract
Total opioid consumption · 24 hours
P = 0.49
Secondary outcomes
Pain scores, opioid-related adverse effects, LOS, patient satisfaction, ongoing opioid use at 1 and 3 months
- No statistically significant differences between groups
Original publication
Effect of an opioid-free anesthetic on postoperative opioid consumption after laparoscopic bariatric surgery: a prospective, single-blinded, randomized controlled trial. Reg Anesth Pain Med. Published 5 June 2024. doi:10.
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