Opioid free versus opioid sparing strategies for multimodal antinociception during laparoscopic colectomy: a randomised controlled trial
Authors' conclusion
In patients undergoing laparoscopic colectomy with a multimodal antinociception protocol, OFA, when compared to OSA, did not decrease postoperative opioid consumption.
Study context
- Population
- Consecutive patients undergoing laparoscopic colectomy with multimodal antinociception155 analysed (modified ITT)
- Participants
- 160 patients
- Comparison
- Opioid-free vs opioid-sparing anaesthesia during laparoscopic colectomy
- Primary endpoint
- Cumulative opioid consumption, in oral morphine equivalents (OME)
- Follow-up
- 48 h after surgery
Methodological detailssingle-centre, prospective, superiority, modified intention-to-treat analysis
- Single-centre
- Prospective
- Superiority
- Modified intention-to-treat analysis
Primary result
As reported in the abstract
OME consumption
P = 0.861
Secondary outcomes
Key secondary outcomes (pain scores, opioid-related adverse events, WHODAS quality of life)
- Not different between groups, except bradycardia
- Secondary exploratory outcomes
Safety
Bradycardia
- Three times higher incidence in the opioid-free anesthesia (OFA) group
Original publication
Opioid free versus opioid sparing strategies for multimodal antinociception during laparoscopic colectomy: a randomised controlled trial. Anaesth Crit Care Pain Med. Published 9 October 2024. doi:10.
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