Opioid-free versus opioid-sparing anaesthesia in ambulatory total hip arthroplasty: a randomised controlled trial
Authors' conclusion
When compared with opioid-sparing anaesthesia, opioid-free anaesthesia does not decrease opioid consumption in the first 24 h.
Study context
- Population
- Patients undergoing day-case primary total hip arthroplasty under GA (TIVA, laryngeal mask, multimodal non-opioid analgesia)
- Participants
- 80 patients
- Comparison
- Opioid-free anaesthesia vs opioid-sparing anaesthesia
- Primary endpoint
- Opioid consumption in oral morphine equivalents (OME)
- Follow-up
- First 24 h
Methodological detailssingle-centre, prospective, triple blind
- Single-centre
- Prospective
- Triple blind
Primary result
As reported in the abstract
Median cumulative OME consumption · 24 h
P = 0.7
Further findings
- Pain scores similar and low in both groups, with comparable walking recovery time
Safety
| Outcome | P value |
|---|---|
| Adverse eventsDizziness more frequent in the OSA group | P < 0.05 |
Adverse events
- Adverse events sparse and equivalent in both groups except for dizziness
Original publication
Opioid-free versus opioid-sparing anaesthesia in ambulatory total hip arthroplasty: a randomised controlled trial. Br J Anaesth. Published 2 December 2023. doi:10.
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