Cardiothoracic & vascular anaesthesia
Opioid-free anaesthesia reduces postoperative nausea and vomiting after thoracoscopic lung resection: a randomised controlled trial
Primary resultResult — go to the resultOdds ratio 0.38 95% CI 0.16–0.91Authors' conclusion
In the context of PONV prophylaxis and multimodal analgesia, SPI-guided opioid-free anaesthesia halved the incidence of PONV after thoracoscopic lung resection, although it was associated with a longer stay in the PACU.
Study context
- Population
- Adults undergoing thoracoscopic lung resection, with postoperative nausea and vomiting (PONV) prophylaxis (dexamethasone, ondansetron) and multimodal analgesia
- Participants
- 120 adults
- Comparison
- Opioid-free anaesthesia (OFA) vs opioid-based anaesthesia
- Primary endpoint
- Occurrence of PONV
- Follow-up
- First 48 h after surgery
Methodological details1:1 allocation stratified by sex, surgical pleth index (SPI)-guided analgesia
- 1:1 allocation stratified by sex
- SPI-guided analgesia
Primary result
As reported in the abstract
Odds ratio
0.38
95% CI 0.16–0.91
P = 0.031
By group
OFA vs Opioid-based anaesthesia
OR 0.38 (95% CI 0.16–0.91); P = 0.031
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| Vomiting | 0.23 (0.08–0.77) | |
| 0.050.21520Odds ratio (log scale) |
| Outcome | Median difference (min) (95% CI) | |
|---|---|---|
| PACU LOS | 15.5 (10–20) | |
| −100102030Difference, min (linear scale) |
Other secondary outcomes
- Comparable between groups
PONV in prespecified subgroups (sex, smoking status, PONV risk scores) (subgroup)
- Effect of OFA on PONV did not differ
Safety
Safety outcomes
- Comparable between groups
Original publication
Opioid-free anaesthesia reduces postoperative nausea and vomiting after thoracoscopic lung resection: a randomised controlled trial. Br J Anaesth. Published 1 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →