Cardiothoracic & vascular anesthesia
Analgesic efficacy of continuous erector spinae plane block vs. opioid‐based regimen for postoperative pain management following video‐assisted thoracoscopic lung resection: a prospective, randomised, open‐label, non‐inferiority trial
Primary result · Cumulative AUC of pain NRS scoreResult — go to the resultMean difference - 0.99 95% CI −11.97-9.98Authors' conclusion
Following video-assisted thoracoscopic lung resection, continuous erector spinae plane block provides non-inferior postoperative analgesia compared with conventional opioid-based regimen whilst enhancing recovery quality significantly and reducing complications.
Study context
- Population
- Patients undergoing video-assisted thoracoscopic lung resection
- Comparison
- Continuous ESP block vs conventional opioid-based regimen
- Primary endpoint
- Overall analgesic efficacy with cough: cumulative AUC of pain NRS scores
- Follow-up
- From PACU discharge to 48 h postoperatively
Methodological detailsprospective, open-label, non-inferiority
- Prospective
- Open-label
- Non-inferiority
Primary result
Cumulative AUC of pain NRS score
Mean difference
- 0.99
95% CI −11.97-9.98
P = 0.011
Continuous ESP block vs Conventional
mean difference - 0.99 (95% CI −11.97-9.98); P = 0.011
As reported in the abstract
Further findings
| Outcome | Median difference (95% CI) | P value | |
|---|---|---|---|
| QoR-15 score · 24 h | 11 (6–16) | P < 0.001 | |
| QoR-15 score · 48 h | 10 (7–15) | P < 0.001 | |
| −1001020Difference (linear scale) |
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| PPCs | 0.45 (0.21–0.96) | P = 0.031 | |
| 0.20.5125Relative risk (log scale) |
Safety
| Outcome | RR (95% CI) | P value | |
|---|---|---|---|
| Postoperative nausea | 0.17 (0.04–0.73) | P = 0.005 | |
| Retching | 0.11 (0.02–0.89) | P = 0.023 | |
| Dizziness | 0.22 (0.07–0.72) | P = 0.005 | |
| 0.050.21520Relative risk (log scale) |
Original publication
Analgesic efficacy of continuous erector spinae plane block vs. opioid‐based regimen for postoperative pain management following video‐assisted thoracoscopic lung resection: a prospective, randomised, open‐label, non‐inferiority trial. Anaesthesia. Published 23 June 2025. doi:10.
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