Cardiothoracic & vascular anaesthesia
Opioid-free Anesthesia in Cardiac Surgery: The OFACAR Randomized Clinical Trial
Primary resultResult — go to the resultRelative risk 0.90 95% CI 0.80–0.99Authors' conclusion
In patients undergoing cardiac surgery with cardiopulmonary bypass, opioid-free anesthesia may reduce composite postoperative complications compared with opioid anesthesia.
Study context
- Population
- Adults undergoing elective cardiac surgery with CPB at two tertiary university hospitals in France, August 2021 to December 2023
- Participants
- 320 adults
- Comparison
- Opioid-free anesthesia (OFA) vs opioid anesthesia with sufentanil
- OFAn = 159
- Controln = 161reference
- Primary endpoint
- Composite of:
- Postoperative neurologic
- Respiratory
- Cardiovascular or renal complications and/or death
- Follow-up
- 30 days after surgery
Methodological detailsblinded, multicentre, superiority
- Blinded
- Multicentre
- Superiority
Primary result
As reported in the abstract
Relative risk
0.90
95% CI 0.80–0.99
P = 0.049
Events by treatment group
OFA vs Control
RR 0.90 (95% CI 0.80–0.99); P = 0.049
Further findings
| Outcome | OFA | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Cardiovascular complications | 64.2% | 75.2% | 0.86 (0.74–0.99) | P = 0.031 | |
| Digestive complications | 2.5% | 11.2% | 0.22 (0.08–0.65) | P = 0.007 | |
| 0.050.21520Relative risk (log scale) |
Postoperative myocardial damage
Events
| Outcome | OFA | Control | P value |
|---|---|---|---|
| Death | 0 | 6 | P = 0.014 |
Original publication
Opioid-free Anesthesia in Cardiac Surgery: The OFACAR Randomized Clinical Trial. Anesthesiology. Published 22 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →