Cardiothoracic & vascular anesthesia
Effect of EEG-guided opioid-free anesthesia on perioperative blood glucose variation in patients undergoing video-assisted thoracic surgery: a secondary analysis of a randomized controlled study
Authors' conclusion
The OFA regimen provides sedation and analgesia comparable to OBA in video-assisted thoracic surgery, but is associated with greater perioperative blood glucose variation.
Study context
- Population
- Patients undergoing video-assisted thoracic surgeryincluded in final analysis
- Participants
- 126 patients
- Comparison
- EEG-guided opioid-free anesthesia vs opioid-based anesthesia
- Opioid-free anesthesia (OFA)n = 64
- Opioid-based anesthesia (OBA)n = 62reference
- Primary endpoint
- Coefficient of variation for glucose (GLUcv) at predefined perioperative time points
Primary result
As reported in the abstract
GLUcv
OFA
22.7
± 9.1
OBA
14.1
± 6.0
P < 0.001
Secondary outcomes
GLUmean
P = 0.003
GLUSD
P < 0.001
Mean amplitude of glycemic excursions (MAGE)
P < 0.001
Largest amplitude of glycemic excursion (LAGE)
P < 0.001
Intraoperative BP, heart rate, sedation and analgesia index; early postoperative pain
- Comparable between groups; no significant difference in early postoperative pain
Original publication
Effect of EEG-guided opioid-free anesthesia on perioperative blood glucose variation in patients undergoing video-assisted thoracic surgery: a secondary analysis of a randomized controlled study. Perioper Med (Lond). Published 3 March 2026. doi:10.
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