Cardiothoracic & vascular anesthesia
Opioid-Free Anesthesia Versus Opioid-Based Anesthesia for Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Pooled result · PONVResult — go to the resultMantel-Haenszel RR 0.52 95% CI 0.35–0.78Authors' conclusion
Compared to OA, OFA reduces the incidence of PONV but showed no significant difference in other clinical outcomes.
Study context
- Population
- Patients undergoing video-assisted thoracoscopic surgery (VATS)
- Participants
- 836 patients · 7 RCTs
- Comparison
- Opioid-free anesthesia vs opioid-based anesthesia
- Outcome
- Postoperative nausea and vomiting (PONV)
Pooled result
As reported in the abstract
Mantel-Haenszel RR
0.52
95% CI 0.35–0.78
OFA vs OA
Mantel-Haenszel RR 0.52 (95% CI 0.35–0.78)
Further pooled results
| Outcome | Estimate | |
|---|---|---|
| Resting postoperative pain | Hedges' g −0.08 (95% CI −0.25 to 0.10) | |
| Dynamic postoperative pain | Hedges' g −0.52 (95% CI −1.26 to 0.22) | |
| Postoperative opioid requirements | Hedges' g −0.12 (95% CI −0.43 to 0.20) | |
| PACU LOS | MD 4.02 (95% CI −3.26 to 11.31) | |
| Hospital LOS | MD 0.35 (95% CI −0.06 to 0.77) | |
| −5051015Difference (linear scale) |
Original publication
Opioid-Free Anesthesia Versus Opioid-Based Anesthesia for Video-Assisted Thoracoscopic Surgery: A Systematic Review and Meta-analysis of Randomized Controlled Trials. J Cardiothorac Vasc Anesth. Published 27 June 2026. doi:10.
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