Opioid-sparing anesthesia based on opioid-free principles for early recovery after total knee arthroplasty: A randomized controlled trial
Primary result · QoR-15Result — go to the resultAdjusted difference 5.12 95% CI 0.51–9.74Authors' conclusion
In TKA, this OFA-based OSA strategy improved early postoperative QoR-15 scores.
Study context
- Population
- Adults scheduled for elective unilateral total knee arthroplasty (TKA)
- Participants
- 98 adults
- Comparison
- Opioid-sparing anesthesia vs opioid-based anesthesia
- Primary endpoint
- QoR-15 score
- Follow-up
- 24 h postoperatively
Methodological detailsblinding of patients, surgeons, and outcome assessors, single-centre, July 2025 to February 2026, Both groups: preoperative femoral nerve block, oxycodone at skin incision and closure, same postoperative multimodal analgesia and PCA
- Blinding of patients, surgeons, and outcome assessors
- Single-centre
- July 2025 to February 2026
- Both groups: preoperative femoral nerve block, oxycodone at skin incision and closure, same postoperative multimodal analgesia and PCA
Primary result
QoR-15 · 24 h
Adjusted difference
5.12
95% CI 0.51–9.74
P = 0.029
By group
OSA
118.4
± 11.5
Opioid-based anesthesia (OBA)
113.3
± 12.2
OSA vs OBA
adjusted difference 5.12 (95% CI 0.51–9.74); P = 0.029
As reported in the abstract
Secondary outcomes
| Outcome | Adjusted difference (95% CI) | P value | |
|---|---|---|---|
| QoR-15 · 48 h | 5.54 (1.57–9.52) | P = 0.007 | |
| Oxford Knee Score · 1 month | 2.31 (0.34–4.27) | P = 0.022 | |
| −50510Difference (linear scale) |
| Outcome | P value |
|---|---|
| Postoperative CRP (exploratory)Lower in OSA | P = 0.001 |
Other secondary outcomes (EQ-5D-3L, high pain at 1 month, chronic postsurgical pain at 3 months, Oxford Knee Score (OKS) at 3 months)
- No significant differences
Safety
| Outcome | P value |
|---|---|
| PONV (exploratory)Lower incidence in OSA | P = 0.025 |
Original publication
Opioid-sparing anesthesia based on opioid-free principles for early recovery after total knee arthroplasty: A randomized controlled trial. J Clin Anesth. Published 22 August 2026. doi:10.
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