Haemodynamics, fluids & transfusion
Effect of Autonomic Nervous System Dysfunction in Breast Cancer Patients on Post-induction and Early Intraoperative Hypotension: A Prospective Observational Study
Authors' conclusion
Despite a high prevalence of ANS dysfunction in breast cancer patients, it was not associated with post-induction hypotension.
Study context
- Population
- Adult women with breast cancer scheduled for surgery under GA69 enrolled
- Participants
- 38 / 25 / 14
- Exposure
- Autonomic nervous system (ANS) dysfunction vs no dysfunction
- Sympathetic dysfunctionn = 38
- Parasympathetic dysfunctionn = 25
- Combined dysfunctionn = 14
- Outcome
- Prevalence of ANS dysfunction (abnormal results in ≥2 tests) and its association with post-induction hypotension (>30% decrease from baseline SBP or SBP <90 mm Hg)
Methodological detailsdouble-blinded, single-centre, September 2018 to August 2019, All India Institute of Medical Sciences (AIIMS), New Delhi
- Double-blinded
- Single-centre
- September 2018 to August 2019, All India Institute of Medical Sciences (AIIMS), New Delhi
Main finding
As reported in the abstract
ANS dysfunction prevalence and association with post-induction hypotension
Odds ratio (95% CI)P value
Sympathetic dysfunction
1.04(0.35–3.07)
P = 1.00Parasympathetic dysfunction
1.17(0.40–3.41)
P = 0.79Combined dysfunction
1.11(0.32–3.87)
P = 1.00- ANS dysfunction prevalence
- 49/62, 79.0%
- Overall incidence of post-induction hypotension
- 22 of 69 (32%)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Age by parasympathetic dysfunction (with vs without)Mean ± SD 52.3 ± 9.7 vs 42.8 ± 9.9 years | P < 0.001 |
| Comorbidities by parasympathetic dysfunction (with vs without)8/25 [32.0%] vs 4/37 [10.8%]; not significant | P = 0.052 |
Original publication
Effect of Autonomic Nervous System Dysfunction in Breast Cancer Patients on Post-induction and Early Intraoperative Hypotension: A Prospective Observational Study. Anesth Analg. Published 24 September 2026. doi:10.
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