Pediatric anesthesia & critical care
Effect of Ciprofol on Left Ventricular Myocardial Strain and Myocardial Work in Children Undergoing Cardiac Surgery: A Single-center Double-blind Randomized Noninferiority Study
Authors' conclusion
Ciprofol did not show different effects on myocardial function and postoperative outcomes from propofol. Further, on the sensitive cardiac systole marker global longitudinal strain, ciprofol demonstrated noninferiority to propofol.
Study context
- Population
- Children aged 1 month to 16 years undergoing atrial or ventricular septal defect surgery with CPB, tertiary centre, Shanghai, China104 completed
- Participants
- 112 children
- Comparison
- Ciprofol vs propofol for anaesthesia induction
- Ciprofoln = 67
- Propofoln = 45reference
Methodological detailssingle-centre, double-blind, non-inferiority, 1.5:1 randomisation
- Single-centre
- Double-blind
- Non-inferiority
- 1.5:1 randomisation
Primary result
As reported in the abstract
Ciprofol
−17.3%
95% CI −18.0%–-16.6%
Propofol
−17.8%
95% CI −18.7–-17.0%
- Lower limit of two-sided 95% CI for intergroup difference (full analysis set)
- 1.58%
Further findings
- Global longitudinal strain (per-protocol set) · after anesthesia — Ciprofol
- −17.5% (95% CI −18.2%–-16.9%)
- Global longitudinal strain (per-protocol set) — Lower limit of two-sided 95% CI for intergroup difference (per-protocol set)
- 1.34%
- Global longitudinal strain (per-protocol set): noninferiority margin 2%; noninferiority confirmed
Left ventricular systolic and diastolic function and myocardial work indices
- No significant differences between groups
Postoperative vasoactive-inotropic score, NT-proBNP, duration of mechanical ventilation, cardiac ICU and hospital LOS
- Comparable between groups (all p > 0.05)
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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