Neuroanesthesia & neurocritical care
Effect of continuous infusion of hypertonic saline solution on survival of patients with brain injury: a systematic review and meta-analysis
Pooled result · In-hospital mortalityResult — go to the resultOdds ratio 0.68 95% CI 0.54–0.85Authors' conclusion
Continuous hypertonic saline solution infusion reduced in-hospital mortality without increasing the risk of unfavorable neurological outcome at day 90 in brain-injured patients hospitalized in intensive care units.
Study context
- Population
- Brain-injured patients hospitalized in ICUs
- Participants
- 1,883 patients · 10 studies
- Comparison
- Continuous infusion of hypertonic saline solution vs no continuous hypertonic saline
- Outcome
- In-hospital mortality rate
Methodological detailsPRISMA guidelines, 23 clinical trials identified, Included observational and heterogeneous studies
- PRISMA guidelines
- 23 clinical trials identified
- Included observational and heterogeneous studies
Pooled result
In-hospital mortality
Odds ratio
0.68
95% CI 0.54–0.85
Continuous infusion of hypertonic saline solution vs no continuous hypertonic saline
OR 0.68 (95% CI 0.54–0.85)
As reported in the abstract
Further pooled results
In-hospital mortality, TBI-only studies (subgroup)
| OR (95% CI) | ||
|---|---|---|
| Intervention7 studies, n = 1521 | 0.74 (0.57–0.95) | |
| 0.512Odds ratio (log scale) |
Intracranial hypertension
| OR (95% CI) | ||
|---|---|---|
| InterventionI2 = 42%, n = 787 | 0.66 (0.49–0.88) | |
| 0.512Odds ratio (log scale) |
Unfavorable neurological outcome · day 90
| OR (95% CI) | ||
|---|---|---|
| InterventionI2 = 15%, n = 956 | 0.61 (0.46–0.81) | |
| 0.512Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Effect of continuous infusion of hypertonic saline solution on survival of patients with brain injury: a systematic review and meta-analysis. Anaesth Crit Care Pain Med. Published 24 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →