Neuroanesthesia & neurocritical care
Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial
Authors' conclusion
Despite a significant increase in chloride intake, a continuous infusion of HSS was not associated with AKI in moderate-to-severe TBI patients.
Study context
- Population
- Patients admitted for moderate-to-severe TBI in 9 ICUs322 analysed
- Participants
- 370 patients
- Comparison
- Continuous 20% hypertonic saline infusion vs standard care
- Primary endpoint
- Occurrence of acute kidney injury (AKI)
- Follow-up
- Within 28 days after enrollment
Methodological detailspost hoc analysis, multicentre
- Post hoc analysis
- Multicentre
Primary result
As reported in the abstract
AKI · 28 days
P = 0.45
Further findings
Chloride intake during first 4 days
P < 0.001
Blood chloride level · day 4
P < 0.001
Original publication
Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial. Crit Care. Published 27 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →