Neuroanesthesia & neurocritical care
Effect of sodium bicarbonate ringer's solution on early renal function and prognosis of patients with traumatic brain injury after surgery: A single-center randomized controlled clinical study
Authors' conclusion
Compared with Lactated ringer's solution, Sodium bicarbonate ringer's solution used for perioperative fluid therapy in patients with TBI can better promote the early recovery of postoperative renal function, and this solution can significantly reduce blood lactate levels,yet this advantage does not translate into a significant impact on patients' postoperative clinical outcomes.
Study context
- Population
- Traumatic brain injury (TBI) patients undergoing emergency open craniocerebral surgery
- Participants
- 124 patients
- Comparison
- SBRS vs LRS
- SBRSn = 62
- LRSn = 62reference
- Primary endpoint
- Creatinine clearance rate (Ccr)
- Follow-up
- 3 days after surgery
Methodological detailssingle-centre, parallel
- Single-centre
- Parallel
Primary result
Ccr · POD 3
Least squares mean difference
−2.36
95% CI −4.13 to −0.59
P = 0.010
By group
As reported in the abstract
Secondary outcomes
| Outcome | SBRS | LRS | Least squares mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Ccr · POD 1Mean, mL/min | 79.8 (SD 9.7) | 76.0 (SD 9.0) | −3.88 (−5.37 to −2.40) | P < 0.001 | |
| Ccr · POD 2Mean, mL/min | 79.9 (SD 9.6) | 75.6 (SD 7.5) | - 4.34 (−5.89 to −2.79) | P < 0.001 | |
| Blood lactate · T2 (end of surgery)Mean, mmol/L | 1.5 (SD 0.7) | 1.7 (SD 0.7) | 0.30 (0.05–0.55) | P = 0.039 | |
| Blood lactate · T3 (12 h after end of surgery)Mean, mmol/L | 1.6 (SD 0.7) | 2.0 (SD 0.6) | 0.38 (0.13–0.62) | P = 0.003 | |
| Serum potassium · T2 (end of surgery)Mean, mmol/L | 3.52 (SD 0.50) | 3.58 (SD 0.52) | 0.14 (0.04–0.24) | P = 0.011 | |
| −10−505Difference (linear scale) |
Other outcomes (incl. mechanical ventilation duration, ICU LOS, hospital LOS, acute kidney injury (AKI), short-term prognosis)
- Other outcomes didn't show statistical differences
Original publication
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