Perioperative medicine & outcomes
Effect of dexmedetomidine infusion on postoperative sleep disturbances in women with breast cancer: A monocentric randomized-controlled double-blind trial
Authors' conclusion
Intra-operative infusion of dexmedetomidine had no significant effect on POSD but decreased nocturnal wakefulness in the sevoflurane group and increased nocturnal deep sleep in the propofol group.
Study context
- Population
- Women undergoing radical surgery for breast cancermodified ITT
- Participants
- 188 women
- Comparison
- Intra-operative dexmedetomidine vs placebo with sevoflurane or propofol
- Primary endpoint
- Incidence of POSD (Athens Insomnia Scale score ≥ 6 points on at least one day)
- Follow-up
- Postoperative first three days
Methodological detailsdouble-blind, monocentric, 2×2 (sevoflurane or propofol, dexmedetomidine or placebo)
- Double-blind
- Monocentric
- 2×2 (sevoflurane or propofol, dexmedetomidine or placebo)
Primary result
As reported in the abstract
Incidence of POSD
- Incidence of postoperative sleep disturbances (POSD) similar with dexmedetomidine and placebo
- Dexmedetomidine vs Placebo: P = 0.649
- Modified intention-to-treat
Secondary outcomes
| Outcome | P value |
|---|---|
| Nocturnal wakefulness (sevoflurane subgroup) · Postoperative first daySevoflurane + dexmedetomidine vs Sevoflurane + placebo · decreased with dexmedetomidine | P = 0.001 |
| Nocturnal deep sleep (propofol subgroup) · Postoperative first and third daysPropofol + dexmedetomidine vs Propofol + placebo · increased with dexmedetomidine, first day | P < 0.001 |
| Nocturnal deep sleep (propofol subgroup) · Postoperative first and third daysPropofol + dexmedetomidine vs Propofol + placebo · increased with dexmedetomidine, third day | P < 0.001 |
- Nocturnal wakefulness (sevoflurane subgroup): Fitbit Charge 2 smart bracelet
Original publication
Effect of dexmedetomidine infusion on postoperative sleep disturbances in women with breast cancer: A monocentric randomized-controlled double-blind trial. Anaesth Crit Care Pain Med. Published 15 February 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →