Effect of Dexmedetomidine on Posttraumatic Stress Disorder in Patients Undergoing Emergency Trauma Surgery: A Randomized Clinical Trial
Primary result · Incidence of PTSDResult — go to the resultAdjusted odds ratio 0.51 95% CI 0.27–0.94Authors' conclusion
In this randomized clinical trial, the administration of intraoperative and postoperative dexmedetomidine reduced the incidence of PTSD among patients with trauma.
Study context
- Population
- Patients with trauma undergoing emergency surgery at 4 hospital centers in Jiangsu Province, China310 in modified ITT analysis
- Participants
- 156 vs 154
- Comparison
- Intraop and postop low-dose IV dexmedetomidine vs placebo
- Dexmedetomidinen = 156
- Normal salinen = 154reference
- Primary endpoint
- Incidence of posttraumatic stress disorder (PTSD) (CAPS-5)
- Follow-up
- 1 month after surgery
Methodological detailsdouble-blind, placebo-controlled, multicentre (4 hospital centers), Conducted January 22 to October 20, 2022; follow-up 1 month postop; observers blinded to groupings
- Double-blind
- Placebo-controlled
- Multicentre (4 hospital centers)
- Conducted January 22 to October 20, 2022; follow-up 1 month postop; observers blinded to groupings
Primary result
Incidence of PTSD · 1 month postoperatively
Adjusted odds ratio
0.51
95% CI 0.27–0.94
P = 0.03
By group
Dexmedetomidine vs Normal saline
aOR 0.51 (95% CI 0.27–0.94); P = 0.03
As reported in the abstract
Secondary outcomes
| Outcome | Dexmedetomidine | Normal saline | Mean difference (95% CI) | P value | |
|---|---|---|---|---|---|
| CAPS-5 score · 1 month postoperatively | 17.3 (SD 5.3) | 18.9 (SD 6.6) | 1.65 (0.31–2.99) | P = 0.02 | |
| −2024Difference (linear scale) |
Original publication
Effect of Dexmedetomidine on Posttraumatic Stress Disorder in Patients Undergoing Emergency Trauma Surgery: A Randomized Clinical Trial. JAMA Netw Open. Published 1 June 2023. doi:10.
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