Effect of Early Administration of Shenfu Injection on Hemodynamics in Septic Patients: A Multicenter, Randomized, Controlled Trial
Authors' conclusion
The early administration of SFI did not decrease the dosage of vasopressors.
Study context
- Population
- ICU patients 18–75 years old meeting Sepsis-3 criteria, 4 tertiary hospitals in central China
- Participants
- 172 patients
- Comparison
- Shenfu injection vs normal saline
- Shenfu injection (SFI)n = 86
- Controln = 86reference
- Primary endpoint
- Amount of vasopressors administered (norepinephrine equivalents [NEEs])
Methodological detailsprospective, multicentre
- Prospective
- Multicentre
Primary result
As reported in the abstract
Total NEE doses
SFI
22.00
range 16.00–29.50
Control
20.00
range 12.50–28.50
P = 0.16
Secondary outcomes
ICU mortality · during ICU stay
P = 0.04
28-day mortality · 28 days after treatment
P = 0.04
Sublingual microcirculation indicators
- Significant improvement in SFI vs control
Safety
- No significant drug-related adverse events in either group
Original publication
Effect of Early Administration of Shenfu Injection on Hemodynamics in Septic Patients: A Multicenter, Randomized, Controlled Trial. Crit Care Med. Published 15 July 2026. doi:10.
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