Effect of early intubation on patient-centered outcomes in urosepsis: a retrospective multicenter cohort study
Authors' conclusion
Early intubation within the first 24 h after ICU admission was not associated with reduced in-hospital or long-term mortality among patients with urosepsis.
Study context
- Population
- Adult ICU patients (≥ 16 years) with a primary diagnosis of urosepsis, Australia and New Zealand, 1 January 2018 to 1 April 2023
- Participants
- 1,235 patients · 151 sites
- Exposure
- Early vs delayed intubation
- Earlyn = 983
- Outcome
- In-hospital mortality
Methodological detailsmulticentre, registry (and New Zealand Intensive Care Society (ANZICS) Adult Patient Database), multivariable logistic or linear regression
- Multicentre
- Registry (ANZICS Adult Patient Database)
- Multivariable logistic or linear regression
Main finding
As reported in the abstract
Adjusted odds ratio
0.76
95% CI 0.51–1.13
P = 0.52
By group
Early vs Delayed
aOR 0.76 (95% CI 0.51–1.13); P = 0.52
Observational data: associations, not effects.
Secondary outcomes
| Outcome | aOR (95% CI) | |
|---|---|---|
| Mortality at 6 months | 0.76 (0.53–1.10) | |
| Mortality at 12 months | 0.75 (0.53–1.06) | |
| 0.512Adjusted odds ratio (log scale) |
| Outcome | Adjusted point estimate (days) (95% CI) |
|---|---|
| ICU LOS | −2.94 (−3.90 to −1.98) |
Hospital lengths of stay (LOS)
- Not shorter with early intubation
Original publication
Effect of early intubation on patient-centered outcomes in urosepsis: a retrospective multicenter cohort study. J Intensive Care. Published 23 October 2025. doi:10.
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