Cardiac arrest & resuscitation
Effect of immunomodulation on post-cardiac arrest brain injury: a systematic review and meta-analysis
Authors' conclusion
Across all studies, immunomodulating therapies were not associated with significant increases in favorable neurologic outcomes or survival.
Study context
- Population
- Adults resuscitated following in- or out-of-hospital cardiac arrest11 studies plus 3 sub-studies
- Participants
- 2,605 adults
- Comparison
- Immunomodulatory therapeutics after cardiac arrest
- Outcome
- Favorable neurological outcome and mortality
Methodological detailsrandom effect model, Cochrane Risk of Bias 2, GRADE, Overall quality of evidence limited by heterogeneous interventions and timing
- Random effect model
- Cochrane Risk of Bias 2
- GRADE
- Overall quality of evidence limited by heterogeneous interventions and timing
Pooled result
As reported in the abstract
Immunomodulatory therapiesRelative risk (95% CI)
Favorable neurological outcome; not associated with an increase
1.04(0.85–1.28)
Mortality; not associated with a decrease
0.97(0.91–1.03)
Further pooled results
IL-6 levels after glucocorticoid administration · 24 h
- Trend toward decreased IL-6 levels
Original publication
Effect of immunomodulation on post-cardiac arrest brain injury: a systematic review and meta-analysis. Resuscitation. Published 11 April 2026. doi:10.
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