Perioperative medicine & outcomes
Effect of incremental positive end-expiratory pressure (PEEP) titration on postoperative pulmonary complications in patients undergoing emergency laparotomy: a randomized controlled trial
Authors' conclusion
Incidence of PPC was not reduced with the use of an individualized PEEP strategy based on lowest driving pressure.
Study context
- Population
- Adults undergoing major emergency laparotomy under GA
- Participants
- 168 adults
- Comparison
- Titrated PEEP vs Fixed PEEP
- Primary endpoint
- PPC
- Follow-up
- Up to POD 7
Primary result
As reported in the abstract
POD 7
Risk of postoperative pulmonary complications (PPC) similar in both study groups, RR
0.81 (0.58, 1.13); p = 0.25 (95% CI)
Further findings
- Oxygen-free days at day 28 similar in two groups
- P = 0.27
- Duration of postoperative hospital stay similar in two groups
- P = 0.50
- Postoperative ICU LOS similar in two groups
- P = 0.28
- In-hospital mortality similar in two groups
- P = 0.38
Safety
- Incidence of intraoperative hypotension similar in two groups
- P = 0.75
Original publication
Effect of incremental PEEP titration on postoperative pulmonary complications in patients undergoing emergency laparotomy: a randomized controlled trial. J Clin Monit Comput. Published 16 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →