Effect of intraoperative methadone in robot‐assisted cystectomy on postoperative opioid requirements: A randomized clinical trial
Authors' conclusion
A single dose of intraoperative methadone does not reduce postoperative opioid requirements compared with a single dose of morphine in bladder cancer patients undergoing RAC.
Study context
- Population
- Bladder cancer patients scheduled for robot-assisted cystectomy99 analysed
- Participants
- 114 patients
- Comparison
- Single intraoperative dose of methadone vs morphine
- Methadonen = 52
- Morphinen = 47reference
- Primary endpoint
- Opioid requirements
- Follow-up
- 24 h
Methodological detailsblinded, July 2020 to August 2023
- Blinded
- July 2020 to August 2023
Primary result
As reported in the abstract
Opioid consumption
P = 0.29
Secondary outcomes
Opioid consumption · 3 h
P = 0.97
Median
| Outcome | Methadone | Morphine | P value |
|---|---|---|---|
| Patient satisfaction (NRS) · 24 h | 9 (IQR 7–10) | 7 (IQR 4–9) | P = 0.020 |
Pain intensity · 48 h
- Significantly lower in the morphine group vs methadone
Time in PACU
- No differences between groups
Safety
Opioid-related side effects
- No differences between groups
Original publication
Effect of intraoperative methadone in robot‐assisted cystectomy on postoperative opioid requirements: A randomized clinical trial. Acta Anaesthesiol Scand. Published 7 November 2024. doi:10.
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