Intraoperative magnesium sulfate is not associated with improved pain control after urologic procedures
Authors' conclusion
Intravenous infusion of magnesium was found to decrease use of AC/BO in the PACU; however, this significance was lost after multivariable analysis stratifying by procedure type.
Study context
- Population
- Patients undergoing robot-assisted radical prostatectomy and endoscopic bladder, prostate and urethral procedures, 2/2021 to 12/2021
- Participants
- 182 patients
- Exposure
- Intraoperative IV magnesium sulfate infusion vs no Mg
- Mgn = 89
- Controln = 93reference
- Outcome
- Use of anticholinergic (AC) and belladonna and opium suppositories (BO), maximum pain score, and MME in PACU
Methodological detailsretrospective review
- Retrospective review
Main finding
AC/BO use in PACU
odds
0.36
95% CI 0.14–0.83
P = 0.02
By group
As reported in the abstract
- No difference in pain score
- P = 0.62
- No difference in morphine milligram equivalents (MME) administration
- P = 0.94
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| Maximum pain score in PACU | P = 0.62 | |
| MME administration in PACU | P = 0.94 | |
| AC/BO use in PACU, multivariable analysisAcross all surgeries | 0.34 | P = 0.02 |
Maximum pain score in postanesthesia care unit (PACU)
- No difference in pain score
MME administration in PACU
- No difference in MME administration
Anticholinergic (AC)/BO use in PACU, bladder procedures (subgroup)
- Only bladder procedures had a significant difference in AC/BO use (9.5% vs. 30.2%; p = 0.02)
- Subgroup univariate analysis
AC/BO use in PACU, multivariable analysis
- Stratifying by procedure type did not find a difference in AC/BO use
Original publication
Intraoperative magnesium sulfate is not associated with improved pain control after urologic procedures. Perioper Med (Lond). Published 6 September 2024. doi:10.
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