Magnesium and Esophageal Pain After Peroral Endoscopic Myotomy of the Esophagus: A Randomized, Double-Blind, Placebo-Controlled Trial
Authors' conclusion
Patients undergoing POEM randomized to receive intraoperative magnesium had sustained reductions in esophageal discomfort severity and opioid requirements 24 hours after surgery.
Study context
- Population
- Patients undergoing peroral endoscopic esophageal myotomy (POEM); standardized intraoperative analgesia
- Participants
- 92 patients
- Comparison
- Intraoperative magnesium sulfate vs 0.9% saline
- Primary endpoint
- Validated, modified Esophageal Symptoms Questionnaire (ESQ) score
- Follow-up
- PACU
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
ESQ score
Median difference
10
95% CI 6–13
P < 0.0001
By group
Magnesium
24
median · IQR 18–31
Saline
35
median · IQR 28–42
Magnesium vs Saline
median difference 10 (95% CI 6–13); P < 0.0001
As reported in the abstract
Further findings
Opioid requirement · PACU
P < 0.0001
99% CI Magnesium 1-9 · Saline 21-37
Opioid requirement · POD 1
P = 0.0009
99% CI Magnesium 0-2.5 · Saline 4-23
Median
| Outcome | Magnesium | Saline | P value |
|---|---|---|---|
| ESQ score · POD 1 | 16 (IQR 14–23) | 30 (IQR 24–35) | P < 0.0001 |
| Pain score · PACU | 0 (IQR 0–3) | 5 (IQR 5–7) | P < 0.0001 |
| Pain score · POD 1 | 0 (IQR 0–2) | 4 (IQR 3–5) | P < 0.0001 |
Original publication
Magnesium and Esophageal Pain After Peroral Endoscopic Myotomy of the Esophagus: A Randomized, Double-Blind, Placebo-Controlled Trial. Anesth Analg. Published 7 June 2024. doi:10.
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