Perioperative medicine & outcomes
Effect of intraperitoneal bupivacaine vs magnesium sulfate on early postoperative outcomes after laparoscopic sleeve gastrectomy: a randomized clinical trial
Authors' conclusion
This study revealed that intraperitoneal administration of bupivacaine at 1, 2, and 4 h postoperatively, and magnesium sulfate at 2, 4, and 6 h postoperatively, significantly reduced pain in patients undergoing sleeve gastrectomy compared to those who didn't receive these analgesics.
Study context
- Population
- Candidates for laparoscopic sleeve gastrectomy, Iran
- Participants
- 105 candidates
- Comparison
- Intraperitoneal bupivacaine vs magnesium sulfate vs normal saline
- Bupivacainen = 35
- Magnesium sulfaten = 35
- Normal salinen = 35reference
- Primary endpoint
- Postoperative pain (VAS)
- Follow-up
- First 24 h after surgery
Methodological detailsthree-arm
- Three-arm
Primary result
As reported in the abstract
Abdominal pain (VAS) · 1, 2, 4, and 6 h post-surgery
- Significant difference in abdominal pain among groups at 1, 2, 4, and 6 h (Kruskal-Wallis)
- P-value < 0.05
Further findings
| Outcome | P value |
|---|---|
| Total rescue analgesic requestsBupivacaine vs Normal saline · significantly lower in the bupivacaine group | P = 0.010 |
Total rescue analgesic requests
- No significant difference between bupivacaine and magnesium sulfate
Postoperative shoulder pain
- Neither drug caused a significant difference
Safety
PONV incidence
- Neither drug caused a significant difference
- P = 0.562
Original publication
Effect of intraperitoneal bupivacaine vs magnesium sulfate on early postoperative outcomes after laparoscopic sleeve gastrectomy: a randomized clinical trial. Perioper Med (Lond). Published 30 September 2025. doi:10.
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