Perioperative medicine & outcomes
Effect of low-dose esketamine on postoperative quality of recovery in total laparoscopic hysterectomy: a randomized controlled trial
Authors' conclusion
In patients undergoing total laparoscopic hysterectomy, one injection of low-dose esketamine at anesthesia induction did not affect QoR-40 scores.
Study context
- Population
- Women scheduled for elective total laparoscopic hysterectomy
- Participants
- 106 women
- Comparison
- Low-dose esketamine at anaesthesia induction vs saline
- Primary endpoint
- Postoperative quality of recovery (QoR-40)
- Follow-up
- 8, 24, 48, and 72 h, 7 days, and 30-day post-surgery
Primary result
As reported in the abstract
QoR-40 scores · each time point
- Similar quality of recovery (QoR-40) scores in both groups at each time point
- P > 0.05
Further findings
Intraoperative remifentanil use
- Less in group S
- P < 0.001
Phenylephrine consumption
- Less in group S
- P = 0.005
Episodes of hypotension
- Fewer in group S
- P < 0.001
Extubation time and postanesthesia care unit (PACU) stay
- Shorter in group S
- P < 0.001
Numerical Rating Scale (NRS) pain scores · after extubation, 8 h and 48 h after surgery
- Lower in group S after extubation
- P = 0.007
- Lower in group S at 8 h
- P = 0.027
- Lower in group S at 48 h
- P = 0.016
Postoperative NLR
- Lower in group S
- P = 0.003
PSQI score · 24 h postoperative
- Lower in group S
- P = 0.024
Mean blood pressure · 10 min after incubation (T3)
- Higher (group S)
- P < 0.001
Heart rate · T1, T3, T4, T5
- Faster in group S at 3 min (T1)
- P = 0.005
- Faster in group S at 10 min (T3)
- P = 0.023
- Faster in group S at 30 min (T4)
- P = 0.014
- Faster in group S at end of surgery (T5)
- P = 0.010
Predictors of recovery (multiple linear regression)
- Higher education associated with better recovery
- P < 0.05
Original publication
Effect of low-dose esketamine on postoperative quality of recovery in total laparoscopic hysterectomy: a randomized controlled trial. Perioper Med (Lond). Published 23 July 2025. doi:10.
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