Opioid-free versus opioid-based anesthesia for quality of recovery following laparoscopic hysterectomy: a randomized controlled non-inferiority trial
Primary result · QoR-15Result — go to the resultMedian difference 2.0 points 95% CI −1.0-4.0Authors' conclusion
Opioid-free anesthesia demonstrated non-inferiority to opioid-based anesthesia for recovery quality while reducing the incidence and severity of PONV.
Study context
- Population
- Women (ASA I–II) undergoing elective laparoscopic hysterectomyall completed follow-up
- Participants
- 110 women
- Comparison
- Opioid-free vs opioid-based GA
- Opioid-freen = 55
- Opioid-basedn = 55reference
- Primary endpoint
- Recovery quality (QoR-15)
- Follow-up
- 24 h
Methodological detailsnon-inferiority, 96% protocol adherence
- Non-inferiority
- 96% protocol adherence
Primary result
QoR-15
Median difference
2.0 points
95% CI −1.0-4.0
P < 0.001
By group
Opioid-free
123
median · IQR 115–127
Opioid-based
121
median · IQR 114–125
Opioid-free vs Opioid-based
median difference 2.0 points (95% CI −1.0-4.0); P < 0.001
As reported in the abstract
Secondary outcomes
| Outcome | Opioid-free | Opioid-based | Estimate | P value | |
|---|---|---|---|---|---|
| PONV incidence | 18.2% | 36.4% | RR 0.50 (95% CI 0.26–0.97) | P = 0.032 | |
| PONV severity | OR 0.39 (95% CI 0.16–0.94) | P = 0.035 | |||
| 0.10.31310Ratio (log scale) |
| Outcome | P value |
|---|---|
| Postoperative morphine consumptionComparable between groups | P = 0.315 |
Safety
- No serious adverse events occurred
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Opioid-free versus opioid-based anesthesia for quality of recovery following laparoscopic hysterectomy: a randomized controlled non-inferiority trial. Anaesth Crit Care Pain Med. Published 20 March 2026. doi:10.
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