Perioperative medicine & outcomes
Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecologic Laparoscopic Surgery: A Double-blind Randomized Controlled Trial
Authors' conclusion
In this single-center randomized trial, pyridoxine plus dexamethasone and ondansetron reduced the incidence of postoperative nausea and vomiting in patients undergoing elective gynecologic laparoscopic surgery under general anesthesia.
Study context
- Population
- Patients aged 18 to 65 yr undergoing elective gynecologic laparoscopic surgery under GA442 screened
- Participants
- 240 patients
- Comparison
- Pyridoxine vs normal saline, plus dexamethasone and ondansetron
- Pyridoxinen = 120
- Controln = 120reference
- Primary endpoint
- Incidence of PONV (patient self-reported)
Methodological detailsdouble-blind, single-centre
- Double-blind
- Single-centre
Primary result
As reported in the abstract
PONV
Each group vs controlRelative risk (95% CI)P value
Pyridoxine
0.47(0.29–0.74)
P = 0.001- Pyridoxine
- absolute risk reduction 0.20 (95% CI 0.08–0.30); P = 0.001
Further findings
| Outcome | Pyridoxine | Control | RR (95% CI) | P value | |
|---|---|---|---|---|---|
| Postoperative nausea | 12.5% | 35% | 0.36 (0.21–0.61) | P < 0.001 | |
| 0.20.5125Relative risk (log scale) |
| Outcome | Absolute risk reduction (95% CI) | P value |
|---|---|---|
| Postoperative nausea | 0.23 (0.12–0.33) | P < 0.001 |
Postoperative vomiting, time to first PONV, pain, serum interleukin-6 and substance P, leukocyte and neutrophil counts
- No statistical differences between groups
Original publication
Pyridoxine Prevents Postoperative Nausea and Vomiting in Gynecologic Laparoscopic Surgery: A Double-blind Randomized Controlled Trial. Anesthesiology. Published 27 December 2024. doi:10.
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