The preventive effect of 5-hydroxytryptamine-3 receptor antagonist on blood pressure reduction and postoperative nausea and vomiting during general anesthesia induction: A double-blinded, randomized controlled trial
Authors' conclusion
Administering ramosetron at anesthesia induction resulted in significantly better hemodynamic stability with significantly lesser requirement of phenylephrine and ephedrine than administering at the end of the surgery did.
Study context
- Population
- Non-smoking patients without past medical history undergoing laparoscopic gynaecological surgery under total intravenous anesthesia (TIVA) with propofol and remifentanil
- Participants
- 176 patients
- Comparison
- Ramosetron at anaesthesia induction vs at end of surgery
Methodological detailsdouble-blinded
- Double-blinded
Primary result
As reported in the abstract
BP at induction and vasopressor requirement
- Significantly higher blood pressure (BP) at induction and significantly lower phenylephrine and ephedrine doses in Induction vs End
Further findings
Postoperative nausea and vomiting (PONV) and postoperative pain
- Similar between the two groups
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
The preventive effect of 5-hydroxytryptamine-3 receptor antagonist on blood pressure reduction and postoperative nausea and vomiting during general anesthesia induction: A double-blinded, randomized controlled trial. J Clin Anesth. Published 24 August 2023. doi:10.
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