Perioperative medicine & outcomes
Efficacy and Safety of Preemptive Magnesium Sulfate Infusion during Pheochromocytoma and Paraganglioma Resection: A Randomized, Double-blind, Placebo-controlled Trial
Authors' conclusion
Preemptive magnesium sulfate infusion effectively reduced intraoperative hemodynamic instability in patients undergoing PPGL resection.
Study context
- Population
- Patients scheduled for pheochromocytoma and paraganglioma (PPGL) resection88 in modified ITT analysis
- Participants
- 92 patients
- Comparison
- Magnesium sulfate vs Placebo
- Primary endpoint
- Intraoperative hemodynamic instability: cumulative time outside BP and heart rate targets (SBP >160 mmHg, MAP <60 mmHg, heart rate >100 beats/min), as % of total anesthesia duration
Methodological detailssingle-centre, double-blind, placebo-controlled
- Single-centre
- Double-blind
- Placebo-controlled
Primary result
As reported in the abstract
P = 0.003
Further findings
Intraoperative maximum SBP
P < 0.001
Patients requiring phentolamine
P = 0.011
Phentolamine dose
P = 0.011
| Outcome | Magnesium sulfate | Placebo |
|---|---|---|
| Peak magnesium concentration (on completion of loading dose) | 1.82 (IQR 1.47–2.14) mmol l −1 | — not stated in the abstract |
— not stated in the abstract
Safety
Safety outcomes
- No significant differences between groups
Original publication
Efficacy and Safety of Preemptive Magnesium Sulfate Infusion during Pheochromocytoma and Paraganglioma Resection: A Randomized, Double-blind, Placebo-controlled Trial. Anesthesiology. Published 3 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →