Perioperative medicine & outcomes
Effect of midodrine on orthostatic intolerance after hip and knee arthroplasty: A randomized controlled trial (the MObILE study)
An erratum to this article was published (J Clin Anesth, Sep 2026 ↗)
Primary result · OI during first mobilizationResult — go to the resultAdjusted relative risk 0.56Authors' conclusion
Regular postoperative administration of midodrine 10 mg is well tolerated and reduces clinically relevant OI during early mobilization following hip and knee arthroplasty
Study context
- Population
- Adults undergoing primary unilateral total hip or knee arthroplasty159 in modified ITT analysis
- Participants
- 170 adults
- Comparison
- Oral midodrine 10 mg vs placebo
- Primary endpoint
- Orthostatic intolerance (OI) during first mobilization
- Follow-up
- POD 0
Methodological detailsdouble-blind, placebo-controlled
- Double-blind
- Placebo-controlled
Primary result
OI during first mobilization
Adjusted relative risk
0.56
P = 0.038
By group
As reported in the abstract
Secondary outcomes
OI · POD 1
unadjusted RR 0.41 · P = 0.064
LOS
Supine SBP and diastolic BP at first mobilization
- Increased with midodrine
Orthostatic hypotension (BP thresholds)
- Incidence did not differ between groups
Safety
| Outcome | Midodrine | Placebo |
|---|---|---|
| Syncope | 0 events | 8% |
Adverse events
- Similar between groups
Original publication
Effect of midodrine on orthostatic intolerance after hip and knee arthroplasty: A randomized controlled trial (the MObILE study). J Clin Anesth. Published 13 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →