Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial
Primary resultResult — go to the resultWin ratio 1.85 95% CI 1.33–2.58Authors' conclusion
Among comatose patients with suspected acute poisoning, a conservative strategy of withholding intubation was associated with a greater clinical benefit for the composite end point of in-hospital death, length of ICU stay, and length of hospital stay.
Study context
- Population
- Comatose patients with suspected acute poisoning and GCS score less than 9, 20 EDs and 1 intensive care unit (ICU) in France, 2021–2023
- Participants
- 225 patients
- Comparison
- Intervention vs Control
- Interventionn = 116
- Controln = 109reference
- Primary endpoint
- Hierarchical composite of:
- In-hospital death
- Length of ICU stay
- Length of hospital stay
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Win ratio
1.85
95% CI 1.33–2.58
Intervention vs Control
win ratio 1.85 (95% CI 1.33–2.58)
Secondary outcomes
Proportion of intubations
Safety
Any adverse event
absolute risk difference 8.6% (−16.6% to −0.7%)
| Outcome | Intervention | Control | Absolute risk difference (95% CI) | |
|---|---|---|---|---|
| Pneumonia within 48 hours | 6.9% | 14.7% | −7.8% (−15.9% to 0.3%) | |
| −20−10010Difference (linear scale) |
Original publication
Effect of Noninvasive Airway Management of Comatose Patients With Acute Poisoning: A Randomized Clinical Trial. JAMA. Published 19 December 2023. doi:10.
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