Noninvasive Ventilation for Preoxygenation during Emergency Intubation
Primary resultResult — go to the resultDifference −9.4 percentage points 95% CI −13.2 to −5.6Authors' conclusion
Among critically ill adults undergoing tracheal intubation, preoxygenation with noninvasive ventilation resulted in a lower incidence of hypoxemia during intubation than preoxygenation with an oxygen mask.
Study context
- Population
- Critically ill adults (≥18 years) undergoing tracheal intubation at 24 EDs and ICUs in the USenrolled
- Participants
- 1,301 adults
- Comparison
- Preoxygenation with NIV vs oxygen mask
- Noninvasive ventilationn = 624
- Oxygen maskn = 637reference
- Primary endpoint
- Hypoxemia during intubation (SpO2 <85% between induction of anesthesia and 2 minutes after tracheal intubation)
Methodological detailsmulticentre
- Multicentre
Primary result
As reported in the abstract
Difference
−9.4 percentage points
95% CI −13.2 to −5.6
P < 0.001
Events by treatment group
Noninvasive ventilation vs Oxygen mask
difference −9.4 percentage points (95% CI −13.2 to −5.6); P < 0.001
Safety
| Outcome | Noninvasive ventilation | Oxygen mask | Difference (percentage points) (95% CI) | |
|---|---|---|---|---|
| Cardiac arrest | 0.2% | 1.1% | −0.9 (−1.8 to −0.1) | |
| Aspiration | 0.9% | 1.4% | −0.4 (−1.6 to 0.7) | |
| −2−101Difference, percentage points (linear scale) |
Original publication
Noninvasive Ventilation for Preoxygenation during Emergency Intubation. N Engl J Med. Published 13 June 2024. doi:10.
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