Pediatric anesthesia & critical care
High-flow Nasal Oxygenation in Infants Undergoing Tracheal Intubation: A Single-center Randomized Controlled Trial
Primary resultResult — go to the resultRelative risk 1.44 95% CI 0.53–3.92Authors' conclusion
In the current study involving the use of HFNO for preoxygenation and apneic oxygenation during tracheal intubation in infants, there was no significant difference in the incidence of desaturation between HFNO and face mask ventilation, although the former was associated with less frequent gastric insufflation.
Study context
- Population
- Infants undergoing elective surgery under tracheal intubation125 analysed
- Participants
- 132 infants
- Comparison
- High-flow nasal oxygenation (HFNO) vs Control
- HFNOn = 60
- Controln = 65reference
- Primary endpoint
- Desaturation incidence (SpO2 <95% for 5 s or longer)
- Follow-up
- From preoxygenation to 1 min after intubation
Methodological detailsprospective, single-centre
- Prospective
- Single-centre
Primary result
As reported in the abstract
Relative risk
1.44
95% CI 0.53–3.92
P = 0.658
By group
HFNO vs Control
RR 1.44 (95% CI 0.53–3.92); P = 0.658
Secondary outcomes
SpO2 <90%, first-attempt intubation success, lowest SpO2, postintubation end-tidal CO2 and oxygen, atelectasis scores
- Similar between groups
Safety
Gastric insufflation · less frequent in the HFNO group
P < 0.001
Original publication
High-flow Nasal Oxygenation in Infants Undergoing Tracheal Intubation: A Single-center Randomized Controlled Trial. Anesthesiology. Published 20 January 2026. doi:10.
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