Haemodynamics, fluids & transfusion
Effect of Preoperative Intravenous Crystalloid Bolus on Postinduction Blood Pressure: A Randomized Blinded Intervention Trial
Authors' conclusion
In this blinded randomized clinical trial, administering a crystalloid fluid bolus within 60 min before surgery did not significantly reduce the time-weighted average of a mean arterial pressure less than 65 mmHg compared to standard care in patients with cardiovascular risk factors undergoing major noncardiac surgery.
Study context
- Population
- Adults ≥45 yr with cardiovascular risk factors undergoing major surgery under GA, two centres in Austriaanalysed
- Participants
- 504 adults
- Comparison
- Preoperative crystalloid bolus vs standard care
- Interventionn = 247
- Standard caren = 257reference
- Primary endpoint
- Time-weighted average MAP <65 mmHg
- Follow-up
- First 20 min after induction or until surgical incision
Methodological detailsprospective, single-blind, two centres
- Prospective
- Single-blind
- Two centres
Primary result
As reported in the abstract
Intervention
0.0
median · IQR 0.0–0.56 · mmHg
Standard care
0.0
median · IQR 0.0–0.84 · mmHg
P = 0.368
Original publication
Effect of Preoperative Intravenous Crystalloid Bolus on Postinduction Blood Pressure: A Randomized Blinded Intervention Trial. Anesthesiology. Published 25 September 2026. doi:10.
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