Perioperative medicine & outcomes
Effect of preoperative oral iron on postoperative morbidity or mortality after major surgery: A French nationwide healthcare database study
Main finding · POD90 morbidity or mortalityResult — go to the resultOdds ratio 0.95 95% CI [0.93, 0.97]Authors' conclusion
In this large, real-world cohort study of patients undergoing major surgery, preoperative oral iron was associated with a lower probability of postoperative morbidity or mortality compared with no iron therapy.
Study context
- Population
- Patients undergoing major surgery (orthopedic, onco-digestive, cardiac, onco-urologic, onco-gynecologic), France, January 2017–September 2019
- Participants
- 947,468 patients · 975,852 surgeries
- Exposure
- Preoperative oral iron vs no iron supplementation
- Oral ironn = 69,377
- Outcome
- Postoperative morbidity (re-hospitalization, VTE, renal insufficiency, infection, stroke/MI, ICU admission) or mortality
- Follow-up
- POD90
Methodological detailsnationwide healthcare database (SNDS), adjusted logistic regression
- Nationwide healthcare database (SNDS)
- Adjusted logistic regression
Main finding
POD90 morbidity or mortality
Odds ratio
0.95
95% CI [0.93, 0.97]
P < 0.001
By group
Oral iron vs no iron
OR 0.95 (95% CI [0.93, 0.97]); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| POD90 mortalityAdjusted logistic regression | 0.85 ([0.79, 0.92]) | P < 0.001 | |
| 0.512Odds ratio (log scale) |
Original publication
Effect of preoperative oral iron on postoperative morbidity or mortality after major surgery: A French nationwide healthcare database study. Anaesth Crit Care Pain Med. Published 20 November 2025. doi:10.
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