Pediatric anesthesia & critical care
Effect of Red Blood Cell Transfusion on Regional Tissue Oxygenation in Pediatric Cardiac Surgery Patients
Authors' conclusion
In this study, neither cerebral nor somatic rSO2 increased significantly post- versus pre-RBC transfusion in pediatric cardiac surgery patients admitted to the ICU after biventricular repairs.
Study context
- Population
- Consecutive pediatric patients (age >28 days to <18 years) after biventricular cardiac surgery, single center, July 2016–April 2020263 transfusion events
- Participants
- 75 patients
- Exposure
- Post- vs pre-RBC transfusion cerebral and somatic rSO2
- Outcome
- Change in cerebral and somatic rSO2 post- vs pre-RBC transfusion
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Median increase, cerebral rSO2
3 percentage points
(−2 to 6)
Median increase, somatic rSO2
2 percentage points
(−3 to 6)
Pre-transfusion
63%
median · IQR 54–71
Observational data: associations, not effects.
Further findings
| Outcome | Mean crSO2 difference (95% CI) | |
|---|---|---|
| Index transfusion: within-patient hemoglobin difference vs crSO2 difference · median 1.15 postoperative days (25th-75th percentile, 0.84-1.93) | 2.54 (0.50–4.48) | |
| −20246Difference (linear scale) |
| Outcome | Pre-transfusion |
|---|---|
| Pretransfusion hemoglobin | median 10.6 (IQR 9.3–11.6) g/dL |
- Index transfusion: within-patient hemoglobin difference vs cerebral rSO2 (crSO2) difference: significantly associated with within-patient hemoglobin difference
Pretransfusion crSO2 ≤50% (events with complete crSO2 data) and posttransfusion crSO2 >50%
- Pretransfusion crSO2 ≤50%: 22 of 138
- 16%
- Posttransfusion crSO2 >50%: 16 of these 22
- 73%
Index transfusion: within-patient hemoglobin difference vs crSO2 difference · median 1.15 postoperative days (25th-75th percentile, 0.84-1.93)
- Between-patient pretransfusion hemoglobin not associated with pretransfusion crSO2
Original publication
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