Neuroanesthesia & neurocritical care
Effect of stellate ganglion block on brain hemodynamics and the inflammatory response in moderate and severe traumatic brain injury: a pilot study
Authors' conclusion
SGB modulates cerebral hemodynamics and lowers intracranial pressure in patients with TBI, demonstrating its potential as a neuroprotective intervention.
Study context
- Population
- Patients with moderate to severe traumatic brain injury (TBI)
- Participants
- 20 patients
- Exposure
- Before vs after ultrasound-guided stellate ganglion block (SGB)
- Outcome
- Change in blood flow velocity in the ipsilateral middle cerebral artery (transcranial color-coded duplex ultrasonography) before and after the procedure
Methodological detailssingle-centre, pilot, before-after
- Single-centre
- Pilot
- Before-after
Main finding
As reported in the abstract
Middle cerebral artery blood flow velocity
- SGB significantly reduced blood flow velocity in the middle cerebral artery
Observational data: associations, not effects.
Secondary outcomes
Basal cerebral artery diameter; cerebral blood flow and volume
- Increased diameter of the large basal cerebral arteries; improved cerebral blood flow and volume in certain ipsilateral brain regions
ICP, cerebral perfusion pressure, brain oxygenation
- ICP decreased; cerebral perfusion pressure and brain tissue oxygen supply improved after SGB
Inflammatory markers (IL-6, S100B) · within 24 hours
- IL-6 and S100B decreased significantly
- Tertiary outcomes
Safety
- No adverse events were observed
Original publication
Effect of stellate ganglion block on brain hemodynamics and the inflammatory response in moderate and severe traumatic brain injury: a pilot study. Reg Anesth Pain Med. Published 19 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →