Effect of sugammadex on processed EEG parameters in patients undergoing robot-assisted radical prostatectomy
Authors' conclusion
After neuromuscular block reversal with 2 mg kg-1 sugammadex, BIS, SEF95, EMG, and beta power showed small but statistically significant increases over time, while delta power decreased.
Study context
- Population
- Adult men undergoing robot-assisted radical prostatectomy under sevoflurane-based GA with continuous rocuronium infusion
- Participants
- 25 men
- Exposure
- After vs before sugammadex 2 mg kg-1 reversal of rocuronium NMB
- Outcome
- Change from baseline in BIS, SEF95, EMG and EEG band power after sugammadex
Methodological detailsBIS, EEG and electromyographic (EMG) measures captured with the BIS Vista monitor
- BIS, EEG and EMG measures captured with the BIS Vista monitor
Main finding
As reported in the abstract
- BIS at 4-6 min vs baseline
- β coefficient 3.63 (95% CI 2.22–5.04); P < 0.001
- SEF95 at 2-4 min vs baseline
- β coefficient 0.29 (95% CI 0.05–0.52); P = 0.016
- SEF95 at 4-6 min vs baseline
- β coefficient 0.71 (95% CI 0.47–0.94); P < 0.001
- EMG at 4-6 min vs baseline
- β coefficient 1.91 (95% CI 1.00–2.81); P < 0.001
- Beta power at 2-4 min vs baseline
- β coefficient 93 (95% CI 1–185); P = 0.046
- Beta power at 4-6 min vs baseline
- β coefficient 208 (95% CI 116–300); P < 0.001
- Delta power at 4-6 min vs baseline
- β coefficient −526.72 (95% CI −778 to −276); P < 0.001
Observational data: associations, not effects.
Further findings
SEF95 and frequency band data adjusted for EMG
- No substantial differences
Safety
- Patients with clinical signs of awakening
- 0
Original publication
Effect of sugammadex on processed EEG parameters in patients undergoing robot-assisted radical prostatectomy. Br J Anaesth. Published 6 July 2023. doi:10.
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