Perioperative medicine & outcomes
The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials
Pooled result · PONVResult — go to the resultRelative risk 0.77 95% CI 0.66–0.89Authors' conclusion
Moderate quality evidence shows that perioperative benzodiazepine administration decreases the incidence of PONV.
Study context
- Population
- Adults undergoing inpatient surgery119 randomised controlled trials (RCTs)
- Comparison
- Perioperative benzodiazepines vs non-benzodiazepine comparators
- Outcome
- PONV
Methodological detailsrandom-effects model, Grading of Recommendations, Assessment, Development and Evaluation (GRADE)
- Random-effects model
- GRADE
Pooled result
As reported in the abstract
Relative risk
0.77
95% CI 0.66–0.89
Benzodiazepines vs Non-benzodiazepine comparators
RR 0.77 (95% CI 0.66–0.89)
Further pooled results
| Outcome | RR (95% CI) | |
|---|---|---|
| Postoperative nausea55 studies, n=5916; NNT 21 · moderate certainty | 0.72 (0.62–0.83) | |
| Postoperative vomiting52 studies, n=5909; NNT 55 · moderate certainty | 0.74 (0.60–0.91) | |
| 0.512Relative risk (log scale) |
Original publication
The effect of perioperative benzodiazepine administration on postoperative nausea and vomiting: a systematic review and meta-analysis of randomised controlled trials. Br J Anaesth. Published 4 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →